![]() ![]() On the other hand lock and key theory explains the binding of perfectly matching or fitting substrate and enzyme. The binding of substrate induces the conformation change of the active site of the enzyme for correct binding. The induced fit theory explains the binding of enzyme and substrate when they are not perfectly matched with each other by their shapes. The following infographic presents the difference between Induced Fit and Lock and Key in a tabular form. ![]() The active site is not static in the induced fit model while it is static in lock and key model. The induced fit theory describes the binding of an enzyme and substrate that are not complementary while lock and key describe the binding of enzyme and substrate that are complementary. Induced fit and lock and key are two theories that explain the mode of an enzyme. What is the Difference Between Induced Fit and Lock and Key?
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